Letteratura Scientifica

Henriette Hummler 1,2 , Cordula Stillhart 1 , Lisa Meilicke 2, Michael Grimm 2 , Elischa Krause 3 ,
Marwan Mannaa 4, Maik Gollasch 4, WernerWeitschies 2 and Susanne Page 1,*

Beatrice Arosio 1 , Riccardo Calvani 2,3 , Evelyn Ferri 4, Hélio José Coelho-Junior 3 , Angelica Carandina 1 ,
Federica Campanelli 5, Veronica Ghiglieri 2,6 , Emanuele Marzetti 2,3,* and Anna Picca 2,7

Szu-Yun Wu 1 , Yu-Yao Cheng 2, Hsing-Yi Chang 3 , Pei-Hsuan Wang 1, I-Ching Hsieh 1, Nai-Hua Yeh 1,
Kuo-Chin Huang 4 and Wen-Harn Pan 1,3,5,*

Caterina Trevisan1,2,3*†, Marianna Noale4†, Giancarlo Zatti1, Davide Liborio Vetrano3,5, Stefania Maggi4 and Giuseppe Sergi1

Abstract

Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial phenotypes. We operationalized a biopsychosocial frailty construct, estimating its association with mild cognitive impairment (MCI) and its subtypes.

he benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.

Current randomized trial evidence on the effect of physical activity (PA) intervention on cognitive function is scarce and mainly found in well-educated populations, limiting its generalizability. Furthermore, the modification effect of education levels remains understudied. We conducted a cluster randomized trial to evaluate the effects of PA intervention on cognitive function in a general older population, and whether education modifies such effects.