Letteratura Scientifica

The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity to Aβ soluble protofibrils, is being tested in persons with early Alzheimer’s disease.

It is widely thought that lifespans are increasing globally. However, life expectancy has begun to stagnate in the UK, and is falling in more than 50 countries including the USA. Lifespan stagnation or decrease is a consequence of socioeconomic inequalities, lifestyle factors, and the COVID-19 pandemic.

Although 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality.

Darae Ko, MD, MSc; Kueiyu Joshua Lin, MD, ScD; Lily G. Bessette, MS; Su Been Lee, BA; Allan J.Walkey,MD, MSc; Susan Cheng, MD, MMSc, MPH; Erin Kim, BS; Robert J. Glynn, PhD, ScD; Dae Hyun Kim, MD, ScD

Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)

Developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies

Developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Aim: To provide a geriatric perspective on the 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio–Thoracic Surgery (EACTS).