Letteratura Scientifica

he benefits and risks of augmenting or switching antidepressants in older adults with treatment-resistant depression have not been extensively studied.

Current randomized trial evidence on the effect of physical activity (PA) intervention on cognitive function is scarce and mainly found in well-educated populations, limiting its generalizability. Furthermore, the modification effect of education levels remains understudied. We conducted a cluster randomized trial to evaluate the effects of PA intervention on cognitive function in a general older population, and whether education modifies such effects.

To examine whether social participation affects the association between frailty and disability.

The frailty and biological age iceberg. The traditional paradigm of medicine bases on the biological model of disease, established when the large majority of diseases was of acute nature. This model prevalently addresses morbidity and chronological age for clinical decision-making and is strongly associated with high healthcare costs and poor quality of life. With the rapid increase and highest prevalence of chronic noncommunicable diseases of the past decades, however, contemporary medicine is more and more adopting a multidimensional, biopsychosocial concept of health and disease.

Studies revealed unidirectional associations between frailty and medication-related problems (MRPs) among older adults. Less is known about the association between frailty and the risk of MRPs. We aimed to assess the bi-directional association between frailty and the risk of MRPs in community-dwelling older adults in five European countries

Dementia Day Care Centres (DDCCs) are defined as services providing care and rehabilitation to people with dementia associated with behavioural and psychological symptoms (BPSD) in a semi-residential setting. According to available evidence, DDCCs may decrease BPSD, depressive symptoms and caregiver burden. The present position paper reports a consensus of Italian experts of different disciplines regarding DDCCs and includes recommendations about architectural features, requirements of personnel, sychosocial interventions, management of psychoactive drug treatment, prevention and care of geriatric syndromes, and support to family caregivers.

Abstract: After a detailed description of orexins and their roles in sleep and other medical disorders, we discuss here the current clinical evidence on the effects of dual (DORAs) or selective (SORAs) orexin receptor antagonists on insomnia with the aim to provide recommendations for their further assessment in a context of personalized and precision medicine

Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished...