Letteratura Scientifica

Occhipinti Giuseppina, Catalani Filippo, Zorzi Alessandro, Bensi Elisa, Patetta Lavinia Maria Alessandra, Scilla Foti Adele, Curreri Chiara, Zanforlini Bruno Micael, Sergi Giuseppe

Tagliavento Marco, Cocomazzi Anna Grazia, Ceccherini Filippo Nicolò, Travaglini Emma Giulia, Macchione Ilaria Giovanna, Bianco Anna Rita, Ercolani Sara, Serra Rocco, Mecocci Patrizia, Boccardi Virginia

Giani Anna, Mazzali Gloria, Nicolussi Paolaz Serena, Mattachini Elisa, Macchi Federica, Santuz Beatrice, Varalta Anna, Mauro Zamboni

Frailty is a multiply determined, age-related state of increased risk for adverse health outcomes. We review how the degree of frailty conditions the development of late-life diseases and modifies their expression.

The role of the cerebellum in neurodegenerative disorders that target cognitive functions has been a subject of increasing interest over the past years. However, a review focused on making clinicians more aware of the role of the cerebellum in dementia is still missing. [...]

Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence on the aging-related pathophysiology underpinning the clinical presentation of physical frailty as a phenotype of a clinical syndrome that is distinct from the cumulative-deficit-based frailty index. [...]

Alzheimer’s Disease (AD) is the most common form of dementia characterized by severe neurodegeneration, neuroinflammation, and the progressive loss of cognitive abilities. [...]

Systemic cancer and ischemic stroke are common conditions and two of the most frequent causes of death among the elderly. The association between cancer and stroke has been reported worldwide. Stroke causes severe disability for cancer patients, while cancer increases the risk of stroke. [...]